Article
Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans.
Breast cancer research and treatment - 1 Jul 2008
Huo Dezheng, Kim Hee-Jin, Adebamowo Clement A, Ogundiran Temidayo O, Akang Effiong E, Campbell Oladapo, Adenipekun Adeniyi, Niu Qun, Sveen Lise, Fackenthal James D, Fackenthal Donna Lee, Das Soma, Cox Nancy, Di Rienzo Anna, Olopade Olufunmilayo I
Abstract excerpt
The UDP-glucuronosylatransferase 1A1 (UGT1A1) gene is involved in the metabolism of estrogen and detoxification of potential carcinogens. The number of TA repeats in the promoter region of UGT1A1 has been linked to breast cancer risk, but results varied by race. We performed a comprehensive assessment of genetic polymorphisms in the UGT1A1 gene, and examined these polymorphisms and TA repeats in relation to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.