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Helix-hairpin-helix protein MJ1434 from Methanocaldococcus jannaschii and EndoIV homologue TTC0482 from Thermus thermophilus HB27 do not process DNA uracil residues.

Nucleic acids research - 1 Aug 2010

Schomacher Lars, Smolorz Sabine, Ciirdaeva Elena, Ber Svetlana, Kramer Wilfried, Fritz Hans-Joachim

Abstract excerpt

The mutagenic threat of hydrolytic DNA cytosine deamination is met mostly by uracil DNA glycosylases (UDG) initiating base excision repair. However, several sequenced genomes of archaeal organisms are devoid of genes coding for homologues of the otherwise ubiquitous UDG superfamily of proteins. Previously, two possible solutions to this problem were offered by (i) a report of a newly discovered family of uracil...

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Identifiers

PMID: 20410075
DOI: 10.1093/nar/gkq270
PMCID: PMC2926615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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