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Article

Physical and functional interactions between uracil-DNA glycosylase and proliferating cell nuclear antigen from the euryarchaeon Pyrococcus furiosus.

The Journal of biological chemistry - 29 Aug 2008

Kiyonari Shinichi, Uchimura Maiko, Shirai Tsuyoshi, Ishino Yoshizumi

Abstract excerpt

Uracil-DNA glycosylase (UDG) is an important repair enzyme in all organisms to remove uracil bases from DNA. Recent biochemical studies have revealed that human nuclear UDG (UNG2) forms a multiprotein complex in replication foci and initiates the base excision repair pathway by interacting with proliferating cell nuclear antigen (PCNA). Here, we show the physical and functional interactions between UDG and PCNA...

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Source

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Identifiers

PMID: 18562313
DOI: 10.1074/jbc.M802837200
PMCID: PMC3259797

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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