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Article

Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Aug 2015

Wikramaratna Paul S, Lourenço José, Klenerman Paul, Pybus Oliver G, Gupta Sunetra

Abstract excerpt

Despite substantial advances in our knowledge of immune responses against HIV-1 and of its evolution within the host, it remains unclear why control of the virus eventually breaks down. Here, we present a new theoretical framework for the infection dynamics of HIV-1 that combines antibody and CD8(+) T-cell responses, notably taking into account their different lifespans. Several apparent paradoxes in HIV...

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Source

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Identifiers

PMID: 26150656
DOI: 10.1098/rstb.2014.0290
PMCID: PMC4528488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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