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Article

Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence.

Journal of virology - 1 Jul 2000

Seiler P, Senn B M, Klenerman P, Kalinke U, Hengartner H, Zinkernagel R M

Abstract excerpt

Poorly cytopathic or noncytopathic viruses can escape immune surveillance and establish a chronic infection. Here we exploited the strategy of combining antiviral drug treatment with the induction of a neutralizing antibody response to avoid the appearance of neutralization-resistant virus variants. Despite the fact that H25 immunoglobulin transgenic mice infected with lymphocytic choriomeningitis virus mounted...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10846070
DOI: 10.1128/jvi.74.13.5896-5901.2000
PMCID: PMC112085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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