Article
The importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domains.
Journal of molecular biology - 8 Jun 2001
Jung S, Spinelli S, Schimmele B, Honegger A, Pugliese L, Cambillau C, Plückthun A
Abstract excerpt
The N-terminal segment (FR-H1) of the heavy chain (V(H)) of antibodies shows significant conformational variability correlating with the nature of the amino acids H6, H7 and H10 (Kabat H9). In this study, we have established a causal relationship between the local sequence and the structure of this framework region and linked this relationship to important biophysical properties such as affinity, folding yield...
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