Article
Structural consensus among antibodies defines the antigen binding site.
PLoS computational biology - 1 Jan 2012
Kunik Vered, Peters Bjoern, Ofran Yanay
Abstract excerpt
The Complementarity Determining Regions (CDRs) of antibodies are assumed to account for the antigen recognition and binding and thus to contain also the antigen binding site. CDRs are typically discerned by searching for regions that are most different, in sequence or in structure, between different antibodies. Here, we show that ~20% of the antibody residues that actually bind the antigen fall outside the CDRs....
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