Importance of a CDR H3 basal residue in V(H)/V(L) interaction of human antibodies.

Abstract excerpt

Although the cooperativity of the V(H) and V(L) domains of an antibody in antigen binding has been extensively studied, the interaction between the V(H) and V(L) domains had not received sufficient attention. To systematically investigate the relationship between the amino acid sequence and V(H)/V(L) interaction strength, we here used a set of anti-bovine serum albumin antibodies having a single human framework...

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