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Article

Structural diversity in a human antibody germline library

21 May 2016

Abstract excerpt

To support antibody therapeutic development, the crystal structures of a set of 16 germline variants composed of 4 different kappa light chains paired with 4 different heavy chains have been determined. All four heavy chains of the antigen-binding fragments (Fabs) have the same complementarity-determining region (CDR) H3 that was reported in an earlier Fab structure. The structure analyses include comparisons of...

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PMID: 27210805
DOI: 10.1080/19420862.2016.1190060

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