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Article

Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution.

Frontiers in immunology - 1 Jan 2021

Fernández-Quintero Monica L, Kroell Katharina B, Hofer Florian, Riccabona Jakob R, Liedl Klaus R

Abstract excerpt

Characterizing and understanding the antibody binding interface have become a pre-requisite for rational antibody design and engineering. The antigen-binding site is formed by six hypervariable loops, known as the complementarity determining regions (CDRs) and by the relative interdomain orientation (VH-VL). Antibody CDR loops with a certain sequence have been thought to be limited to a single static canonical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33737932
DOI: 10.3389/fimmu.2021.630034
PMCID: PMC7960778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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