Article
Genome screen for quantitative trait loci underlying normal variation in femoral structure.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2001
Koller D L, Liu G, Econs M J, Hui S L, Morin P A, Joslyn G, Rodriguez L A, Conneally P M, Christian J C, Johnston C C, Foroud T, Peacock M
Abstract excerpt
Femoral structure contributes to bone strength at the proximal femur and predicts hip fracture risk independently of bone mass. Quantitative components of femoral structure are highly heritable traits. To identify genetic loci underlying variation in these structural phenotypes, we conducted an autosomal genome screen in 309 white sister pairs. Seven structural variables were measured from femoral radiographs and...
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