Article
Linkage of structure at the proximal femur to chromosomes 3, 7, 8, and 19.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2003
Koller D L, White K E, Liu G, Hui S L, Conneally P M, Johnston C C, Econs M J, Foroud T, Peacock M
Abstract excerpt
Risk for osteoporotic fracture is determined in part by femoral structure, which is under genetic control. We conducted a genome scan in 638 sister-pairs for structure phenotypes. Significant evidence of linkage was detected with several chromosomal regions, including confirmation of our prior linkage findings. Bone strength and resistance to fracture at the proximal femur is determined in part by structural...
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