Article
Hereditary nonpolyposis colorectal cancer with gynecologic malignancies: report of two families in Taiwan.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Apr 2001
Chen C H, Huang R L, Yu M S, Wong L J, Chao T F, Chu T Y
Abstract excerpt
Hereditary nonpolyposis colon cancer (HNPCC), also known as Lynch syndrome, is characterized by germline and somatic mutations of DNA mismatch repair genes with dominant inheritance of site-specific colorectal cancer or colorectal cancer plus cancers of extracolonic sites. We describe two Taiwanese HNPCC families with members who had predominantly gynecologic malignancies. In one family, the 53-year-old proband...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
