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Article

Cancer risk in mutation carriers of DNA-mismatch-repair genes

12 Apr 1999

Abstract excerpt

Excessive incidence of various cancers is a challenging feature of the hereditary-non-polyposis-colorectal-cancer (HNPCC) syndrome. This study estimated the cancer incidences in HNPCC compared with the general population. Individuals in a cohort of 1763 members of 50 genetically diagnosed families were categorized according to their genetic status as mutation carriers, non-carriers, or individuals at 50 or 25%...

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Identifiers

PMID: 10188721
DOI: 10.1002/(sici)1097-0215(19990412)81:2<214::aid-ijc8>3.0.co;2-l

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