Article
Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome.
Deutsches Arzteblatt international - 1 Jan 2013
Steinke Verena, Engel Christoph, Büttner Reinhard, Schackert Hans Konrad, Schmiegel Wolff H, Propping Peter
Abstract excerpt
BACKGROUND: Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of four genes of the DNA mismatch repair system and confers a markedly increased risk for various types of cancer, particularly of the colon and the endometrium. Its prevalence in the general population is about 1 in 500, and it causes about 2% to...
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