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Article

Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR.

The Journal of biological chemistry - 27 Apr 2001

Wong A H, Durbin J E, Li S, Dever T E, Decker T, Koromilas A E

Abstract excerpt

We have previously reported a physical association between STAT1 and the protein kinase double-stranded RNA-activated protein kinase (PKR). PKR inhibited STAT1 function in a manner independent of PKR kinase activity. In this report, we have further characterized the properties of both molecules b...

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Source

Identifiers

PMID: 11278865
DOI: 10.1074/jbc.M011240200

Genes

STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11278865-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR.PMID 11278865Read ↗

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Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.Semantic proximity Read ↗

Stat1-independent regulation of gene expression in response to IFN-γSemantic proximity Read ↗

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.Semantic proximity Read ↗

Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation.Semantic proximity Read ↗

Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.Semantic proximity Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

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