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Article

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease.

Cell - 9 Feb 1996

Durbin J E, Hackenmiller R, Simon M C, Levy D E

Abstract excerpt

The STAT1 transcription factor is activated in response to many cytokines and growth factors. To study the requirement for STAT1 in vivo, we disrupted the Stat1 gene in embryonic stem (ES) cells and in mice. Stat1(-1-)ES cells were unresponsive to interferon (IFN), but retained responsiveness to leukemia inhibitory factor (LIF) and remained LIF dependent for undifferentiated growth. Stat1(-1-1) animals were born...

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Source

Identifiers

PMID: 8608598
DOI: 10.1016/s0092-8674(00)81289-1

Genes

STAT1
LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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