Article
Noncytolytic human lymphocytes injure dermal microvessels in the huPBL-SCID skin graft model.
Human immunology - 1 Jun 2001
Rayner D, Nelson R, Murray A G
Abstract excerpt
Recent transplantation experiments using perforin-deficient mice as allograft recipients have challenged the concept that allograft rejection is mediated exclusively by CTL. We sought to determine if human noncytolytic lymphocytes could mediate rejection of allogeneic human skin grafts in the huPBL-SCID mouse model of rejection. We generated short term lines of human lymphocytes from peripheral blood mononuclear...
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