Article
Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.
The Journal of experimental medicine - 1 Apr 1990
Young J W, Steinman R M
Abstract excerpt
Cytotoxic lymphocytes are typically generated from unfractionated suspensions of human lymphocytes by stimulating with heterogeneous APCs and exogeneous growth factors. We have found that human blood dendritic cells can directly stimulate allogeneic human CD8+ T cells to proliferate and express antigen-specific cytotoxic activity. These primary responses, which are accompanied by the release of T cell growth...
Topics
- Antigens, CD
- CD4 Antigens
- Cell Communication
- Cell Separation
- Cells, Cultured
- Centrifugation, Density Gradient
- Cytotoxicity, Immunologic
- Dendritic Cells
- Humans
- Interleukin-2
- Leukocytes