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Article

Xenospecific cytotoxic T lymphocytes: potent lysis in vitro and in vivo.

Transplantation - 27 Apr 1997

Smyth M J, Kershaw M H, Trapani J A

Abstract excerpt

As little is known about the molecular mechanisms responsible for lymphocyte-mediated rejection of xenografts, we have studied the relative contribution of perforin and Fas pathways in cytotoxic lymphocytes generated in mice transplanted with human cell lines. Responder lymphocytes generated in immunocompetent mice displayed significant lysis of human target cells, which suggests that mice can generate a strong...

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Identifiers

PMID: 9133481
DOI: 10.1097/00007890-199704270-00019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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