Article
Xenospecific cytotoxic T lymphocytes: potent lysis in vitro and in vivo.
Transplantation - 27 Apr 1997
Smyth M J, Kershaw M H, Trapani J A
Abstract excerpt
As little is known about the molecular mechanisms responsible for lymphocyte-mediated rejection of xenografts, we have studied the relative contribution of perforin and Fas pathways in cytotoxic lymphocytes generated in mice transplanted with human cell lines. Responder lymphocytes generated in i...
Topics
- Animals
- Antibodies, Monoclonal
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Fas Ligand Protein
- Graft Rejection
- Humans
- Immunity, Cellular
- Jurkat Cells
- Killer Cells, Natural
- Leukemia-Lymphoma, Adult T-Cell
- Membrane Glycoproteins
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Perforin
- Phenotype
- Pore Forming Cytotoxic Proteins