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Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant.

Molecular and cellular biology - 1 Jan 1996

Plyte S E, Feoktistova A, Burke J D, Woodgett J R, Gould K L

Abstract excerpt

We report the cloning of the skp1+ gene, a Schizosaccharomyces pombe homolog of the glycogen synthase kinase 3 (GSK-3) family whose members in higher eukaryotes are involved in cell fate determination, nuclear signalling, and hormonal regulation. skp1 is 67% identical to mammalian GSK-3 beta and displays similar biochemical properties in vitro. Like GSK-3 beta, skp1 is phosphorylated on a conserved tyrosine...

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Identifiers

PMID: 8524294
DOI: 10.1128/MCB.16.1.179
PMCID: PMC230991

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