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Article

Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain protein, Skb5.

The Journal of biological chemistry - 17 Dec 1999

Yang P, Pimental R, Lai H, Marcus S

Abstract excerpt

The p21-activated kinase (PAK) homolog Shk1 is essential for cell viability in the fission yeast Schizosaccharomyces pombe. Roles have been established for Shk1 in the regulation of cell morphology, sexual differentiation, and mitosis in S. pombe. In this report, we describe the genetic and molecular characterization of a novel SH3 domain protein, Skb5, identified as a result of a two-hybrid screen for Shk1...

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Identifiers

PMID: 10593886
DOI: 10.1074/jbc.274.51.36052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain protein, Skb5.PMID 10593886Read ↗

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Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant.Semantic proximity Read ↗

The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway.Semantic proximity Read ↗

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