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Article

Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.

Molecular biology of the cell - 1 Jun 2008

Pérez-Victoria F Javier, Mardones Gonzalo A, Bonifacino Juan S

Abstract excerpt

The biosynthetic sorting of acid hydrolases to lysosomes relies on transmembrane, mannose 6-phosphate receptors (MPRs) that cycle between the TGN and endosomes. Herein we report that maintenance of this cycling requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex. Depletion of any of the three GARP subunits, Vps52, Vps53, or Vps54, by RNAi impairs sorting of the precursor of...

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Identifiers

PMID: 18367545
DOI: 10.1091/mbc.e07-11-1189
PMCID: PMC2397299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.PMID 18367545Read ↗

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Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex.Semantic proximity Read ↗

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VPS54 and the wobbler mouseSemantic proximity Read ↗

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationSemantic proximity Read ↗

A Neurodevelopmental Disorder Caused by Mutations in the VPS51 Subunit of the GARP and EARP ComplexesSemantic proximity Read ↗

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Mammalian VPS45 orchestrates trafficking through the endosomal systemSemantic proximity Read ↗

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