Article
Clonal expansion of different mtDNA variants without selective advantage in solid tumors.
Mutation research - 9 Mar 2009
Gekeler Julia, Zsurka Gábor, Kunz Wolfram S, Preuss Simon F, Klussmann Jens Peter, Guntinas-Lichius Orlando, Wiesner Rudolf J
Abstract excerpt
In search of tumor-specific mitochondrial DNA (mtDNA) mutations in head and neck squamous cell cancer, we found heteroplasmy in the blood of two individuals, i.e., these individuals carried two alleles of mtDNA. In both cases, the tumor was found to be homoplasmic, i.e., it contained only one of the two mtDNA alleles present in blood. More interestingly, in one case the tumor had acquired the wild-type allele,...
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