Article

Distinguishing excess mutations and increased cell death based on variant allele frequencies

2021-02-13

Abstract excerpt

Tumors often harbor orders of magnitude more mutations than healthy tissues. The increased number of mutations may be due to an elevated mutation rate or frequent cell death and correspondingly rapid cell turnover, or a combination of the two. It is difficult to disentangle these two mechanisms based on widely available bulk sequencing data, where sequences from individual cells are intermixed and, thus, the cell...

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Literature Corpus work: 2f33c6f8-051d-53c8-bb42-ccba1a141ba2
DOI: 10.1101/2021.02.12.430830

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