Article
Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease.
American journal of medical genetics - 8 May 2001
Mann M B, Wu S, Rostamkhani M, Tourtellotte W, MacMurray J, Comings D E
Abstract excerpt
The activity of human phenylethanolamine N-methyltransferase (PNMT) is reduced in the neurons of those cells in many subcortical areas of the brain that are known to undergo neurodegeneration in Alzheimer disease (AD). Others have reported that PNMT is decreased in brains of persons with AD and that the decrease in enzymatic activity is due to a reduced amount of the enzyme protein. We have previously described...
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