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Article

Effect of PSEN1 mutations on MAPT methylation in early-onset Alzheimer's disease.

Current Alzheimer research - 1 Jan 2015

Coupland Kirsten G, Kim Woojin S, Halliday Glenda M, Hallupp Marianne, Dobson-Stone Carol, Kwok John B J

Abstract excerpt

The MAPT gene is a risk locus for multiple neurodegenerative diseases, including idiopathic Parkinson's and Alzheimer's disease. We examined whether altered DNA methylation of the MAPT promoter, with its potential to modulate gene expression, was a common phenomenon in Alzheimer's disease patient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26159201
DOI: 10.2174/1567205012666150710110756

Genes

MAPT
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-26159201-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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