Article
A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression.
Blood - 1 Jun 2001
Tamasauskas D, Powell V, Saksela K, Yazdanbakhsh K
Abstract excerpt
Genetic variations in the CC chemokine receptor (CCR5) leading to reduced or absent expression are associated with resistance to human immunodeficiency virus infection and delayed onset of acquired immunodeficiency syndrome. Similarly, lack of the red-cell chemokine receptor Duffy confers protection against malarial infection by Plasmodium vivax. Investigators have previously described a missense mutation (R89C)...
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