Article
High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene.
BMC genomics - 29 Jul 2008
Carén Helena, Erichsen Jennie, Olsson Linda, Enerbäck Charlotta, Sjöberg Rose-Marie, Abrahamsson Jonas, Kogner Per, Martinsson Tommy
Abstract excerpt
BACKGROUND: Neuroblastoma is a very heterogeneous pediatric tumor of the sympathetic nervous system showing clinically significant patterns of genetic alterations. Favorable tumors usually have near-triploid karyotypes with few structural rearrangements. Aggressive stage 4 tumors often have near-diploid or near-tetraploid karyotypes and structural rearrangements. Whole genome approaches for analysis of...
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