Article
Interaction with mLin-7 alters the targeting of endocytosed transmembrane proteins in mammalian epithelial cells.
Molecular biology of the cell - 1 May 2001
Straight S W, Chen L, Karnak D, Margolis B
Abstract excerpt
To investigate the targeting mechanism for proteins bound to the mammalian Lin-7 (mLin-7) PDZ domain, we created receptor protein chimeras composed of the carboxyl-terminal amino acids of LET-23 fused to truncated nerve growth factor receptor/P75. mLin-7 bound to the chimera with a wild-type LET-23 carboxyl-terminal tail (P75t-Let23WT), but not a mutant tail (P75t-Let23MUT). In Madin-Darby canine kidney (MDCK)...
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