Synthesis of Antiproliferative <i>Cephalotaxus</i> Esters and Their Evaluation against Several Human Hematopoietic and Solid Tumor Cell Lines: Uncovering Differential Susceptibilities to Multidrug Resistance

Abstract excerpt

Deoxyharringtonine (2), homoharringtonine (3), homodeoxyharringtonine (4), and anhydroharringtonine (5) are reported to be among the most potent members of the antileukemia alkaloids isolated from the Cephalotaxus genus. Convergent syntheses of these four natural products are described, each involving novel synthetic methods and strategies. These syntheses enabled evaluation of several advanced natural and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Fungal Plant Pathogen Control
• Share to Metal complexes synthesis and properties