Article
(-)-Roemerine, an aporphine alkaloid from Annona senegalensis that reverses the multidrug-resistance phenotype with cultured cells.
Journal of natural products - 1 Apr 1995
You M, Wickramaratne D B, Silva G L, Chai H, Chagwedera T E, Farnsworth N R, Cordell G A, Kinghorn A D, Pezzuto J M
Abstract excerpt
A known aporphine alkaloid, (-)-roemerine [1], isolated from the leaves of Annona senegalensis, was found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB-V1 cells. In the absence of vinblastine, no significant cytotoxicity was observed with KB-3 or KB-V1 cells (ED50 > 20 micrograms/ml), and several other human tumor cell lines were also relatively insensitive. As indicated by...
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