Article
(-)-Roemerine, an aporphine alkaloid from Annona senegalensis that reverses the multidrug-resistance phenotype with cultured cells.
Journal of natural products - 1 Apr 1995
You M, Wickramaratne D B, Silva G L, Chai H, Chagwedera T E, Farnsworth N R, Cordell G A, Kinghorn A D, Pezzuto J M
Abstract excerpt
A known aporphine alkaloid, (-)-roemerine [1], isolated from the leaves of Annona senegalensis, was found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB-V1 cells. In the absence of vinblastine, no significant cytotoxicity was observed with KB-3 or KB-V1 cell...
Topics
- Africa
- Alkaloids
- Animals
- Antineoplastic Agents, Phytogenic
- Drug Resistance, Multiple
- Drug Screening Assays, Antitumor
- Humans
- In Vitro Techniques
- KB Cells
- Mitochondria, Liver
- Phenotype
- Plants, Medicinal
- Rats
- Tumor Cells, Cultured