Article
Inhibition of P-glycoprotein functionality by vandetanib may reverse cancer cell resistance to doxorubicin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 15 Aug 2012
Jovelet C, Bénard J, Forestier F, Farinotti R, Bidart J M, Gil S
Abstract excerpt
P-glycoprotein belongs to the ATP binding cassette transporters, responsible for the multidrug resistance of cancer cells. These transporters efflux hydrophobic drugs outside cells and decrease their therapeutic efficacy. The aim of this study was to investigate the effect of vandetanib, an oral tyrosine kinase inhibitor of EGFR, VEGFR 2 and RET kinases, on the functionality of P-gp after a 24h-treatment at...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
- Antibiotics, Antineoplastic
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival