Article
Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels.
Journal of lipid research - 1 May 2001
Ko C, Lee T L, Lau P W, Li J, Davis B T, Voyiaziakis E, Allison D B, Chua S C, Huang L S
Abstract excerpt
An elevated plasma apolipoprotein B (apoB) level is a strong predictor of atherosclerosis and coronary heart disease. Epidemiologic and family linkage studies have suggested a genetic basis for the wide variations of plasma apoB levels in the general population. Using a human apoB transgenic (HuBTg) mouse model, we have previously shown that hepatic apoB-100 secretion is a major determinant of the high and low...
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