Article
Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2005
Seidelmann Sara Bretschger, De Luca Carl, Leibel Rudolph L, Breslow Jan L, Tall Alan R, Welch Carrie L
Abstract excerpt
OBJECTIVE: The purpose of this study was to examine genetic factors responsible for metabolic syndrome and atherosclerosis in a setting of low-density lipoprotein (LDL) receptor deficiency in a cross between C57BL/6J (B6) and PERA/Ei (PERA) inbred mouse strains. METHODS AND RESULTS: Comparison of metabolic phenotypes in B6 and PERA strains revealed the PERA genetic background to be dramatically more susceptible...
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