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Article

Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2001

Fukuda N, Jayr C, Lazrak A, Wang Y, Lucas R, Matalon S, Matthay M A

Abstract excerpt

Because tumor necrosis factor (TNF)-alpha can upregulate alveolar fluid clearance (AFC) in pneumonia or septic peritonitis, the mechanisms responsible for the TNF-alpha-mediated increase in epithelial fluid transport were studied. In rats, 5 microg of TNF-alpha in the alveolar instillate increased AFC by 67%. This increase was inhibited by amiloride but not by propranolol. We also tested a triple-mutant TNF-alpha...

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Share to Adrenergic beta-Agonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11350806
DOI: 10.1152/ajplung.2001.280.6.L1258

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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