Article
Membrane interaction of TNF is not sufficient to trigger increase in membrane conductance in mammalian cells.
FEBS letters - 22 Oct 1999
van der Goot F G, Pugin J, Hribar M, Fransen L, Dunant Y, De Baetselier P, Bloc A, Lucas R
Abstract excerpt
Tumor necrosis factor TNF can trigger increases in membrane conductance of mammalian cells in a receptor-independent manner via its lectin-like domain. A lectin-deficient TNF mutant, lacking this activity, was able to bind to artificial liposomes in a pH-dependent manner, but not to insert into the bilayer, just like wild type TNF. A peptide mimicking the lectin-like domain, which can still trigger increases in...
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