Article
BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis.
Shock (Augusta, Ga.) - 1 May 2011
O'Brien Alastair J, Terala Deepti, Orie Nelson N, Davies Nathan A, Zolfaghari Parjam, Singer Mervyn, Clapp Lucie H
Abstract excerpt
Nitric oxide-mediated activation of large conductance calcium-activated potassium (BK) channels is considered an important underlying mechanism of sepsis-induced hypotension. Indeed, the nonselective K-channel inhibitor, tetraethylammonium chloride (TEA), has been proposed as a potential treatment to raise blood pressure in septic shock by virtue of its ability to inhibit BK channels. As experimental evidence has...
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