Article
A human tumor necrosis factor (TNF) alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon.
The Journal of experimental medicine - 1 Apr 1994
Van Zee K J, Stackpole S A, Montegut W J, Rogy M A, Calvano S E, Hsu K C, Chao M, Meschter C L, Loetscher H, Stüber D
Abstract excerpt
A number of recent studies have demonstrated that cellular responses to tumor necrosis factor (TNF) mediated by the p55 and the p75 TNF receptors are distinct. To evaluate the relative in vivo toxicities of wild-type TNF alpha (wtTNF alpha) and a novel p55 TNF selective receptor agonist, healthy, anesthetized baboons (Papio sp.) were infused with a near-lethal dose of either wtTNF alpha or a TNF alpha double...
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