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Article

Contribution of caspase-3 differs by p53 status in apoptosis induced by X-irradiation.

Japanese journal of cancer research : Gann - 1 Apr 2001

Kobayashi D, Tokino T, Watanabe N

Abstract excerpt

We investigated the effect of p53 status on involvement of caspase-3 activation in cell death induced by X-irradiation, using rat embryonic fibroblasts (REFs) transduced with a temperature-sensitive mutant (mt) p53 gene. Cells with wild-type (wt) p53 showed greater resistance to X-irradiation than cells with mt p53. In cells with wt p53, X-irradiation-induced apoptosis was not inhibited by the caspase-3 inhibitor...

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Identifiers

PMID: 11346471
DOI: 10.1111/j.1349-7006.2001.tb01118.x
PMCID: PMC5926727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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