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Article

Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP.

Oncology reports - 1 Jul 2008

Ohnishi Ken, Nagata Yoko, Takahashi Akihisa, Taniguchi Shigeki, Ohnishi Takeo

Abstract excerpt

The X-chromosome-linked inhibitor of the apoptosis protein (XIAP) is known to be an inhibitory factor for caspase-3. The aim of our study was to see whether radiation-induced apoptosis is enhanced by RNA interference targeting the XIAP through an elevation of caspase-3 activity, and whether the effect of XIAP depression depends on the p53 status of cancer cells. Two types of transformed human cultured non-small...

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Share to Apoptosis
Share to Caspase 3
Share to Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Poly(ADP-ribose) Polymerases

Share to Radiation Tolerance

Share to RNA, Small Interfering

Share to X-Linked Inhibitor of Apoptosis Protein

Source

Identifiers

PMID: 18575718

Genes

XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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