Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia.

doi:10.1016/j.atherosclerosis.2004.10.016

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Article

Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia.

Atherosclerosis - 1 Apr 2005

Pisciotta Livia, Cortese Claudio, Gnasso Agostino, Liberatoscioli Laura, Pastore Anna, Mannucci Liliana, Irace Concetta, Federici Giorgio, Bertolini Stefano

Abstract excerpt

Mild hyperhomocysteinemia is considered an important risk factor for vascular disease. A common polymorphism (677C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased enzyme activity and consequent higher circulating levels of homocysteine. We hypothesized that the serum levels of homocysteine and/or the MTHFR polymorphism could influence the risk for coronary artery...

Topics

Adult
Aged
Coronary Artery Disease
Female
Genetic Predisposition to Disease
Genotype
Homocysteine
Humans
Hyperlipoproteinemia Type II
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Odds Ratio

Polymorphism, Genetic

Regression Analysis

Risk Factors

Sex Factors

Source

Open in PubMed

Identifiers

PMID: 15777550
DOI: 10.1016/j.atherosclerosis.2004.10.016

Genes

CAD
MTHFR

Provenance

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Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia.PMID 15777550Read ↗

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