Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2001

Matarese G, Di Giacomo A, Sanna V, Lord G M, Howard J K, Di Tuoro A, Bloom S R, Lechler R I, Zappacosta S, Fontana S

Abstract excerpt

Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction. To study the influence of leptin on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with a myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, with or without leptin replacement, and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypersensitivity, Delayed

Share to Mice, Obese

Share to Myelin-Associated Glycoprotein

Share to Myelin-Oligodendrocyte Glycoprotein

Share to Myelin Proteins

Share to T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 11342605
DOI: 10.4049/jimmunol.166.10.5909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis.PMID 11342605Read ↗

Leptin Receptor Signaling in T Cells Is Required for Th17 DifferentiationSemantic proximity Read ↗

The pleiotropic roles of leptin in metabolism, immunity, and cancer.Semantic proximity Read ↗

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.Semantic proximity Read ↗

Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1G93A mice by reducing inflammatory pathways in the adipose tissueSemantic proximity Read ↗

Beta Adrenergic Signaling as a Therapeutic Target for AutoimmunitySemantic proximity Read ↗

Cutting edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus.Semantic proximity Read ↗

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination.Semantic proximity Read ↗

Effects of diet-induced obesity and voluntary exercise in a tauopathy mouse model: implications of persistent hyperleptinemia and enhanced astrocytic leptin receptor expression.Semantic proximity Read ↗

Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system.Semantic proximity Read ↗

Leptin signaling is required for leucine deprivation-enhanced energy expenditure.Semantic proximity Read ↗

Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.Semantic proximity Read ↗

IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.