Article

Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1G93A mice by reducing inflammatory pathways in the adipose tissue

2023-11-14

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients and animal models. Leptin, an adipose-derived hormone, displays altered levels in ALS. Genetically reducing leptin levels ( Lep ob/+) to maintain body weight improved motor performance and extended survival in female SOD1 G93A mice,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6afc6644-a5d7-51ea-b40b-e316b7f5feb6
DOI: 10.21203/rs.3.rs-3576585/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1G93A mice by reducing inflammatory pathways in the adipose tissueDOI 10.21203/rs.3.rs-3576585/v1Read

Sex-specific hypothalamic axis disruption in the rNLS8 mouse model of amyotrophic lateral sclerosis (ALS)Semantic proximity Read

PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis.Semantic proximity Read

Brown Adipose Tissue undergoes pathological perturbations and shapes C2C12 myoblast homeostasis in the SOD1-G93A mouse model of Amyotrophic Lateral SclerosisSemantic proximity Read

Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS.Semantic proximity Read

The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged miceSemantic proximity Read

Muscle spatial lipidomics identifies early ALS-associated lipid remodeling in presymptomatic SOD1G93A miceSemantic proximity Read

Shared Genetic Links Between Amyotrophic Lateral Sclerosis and Obesity-Related Traits: A Genome-Wide Association StudySemantic proximity Read

Structure, production and signaling of leptin.Semantic proximity Read

Heterozygous Lepr Mutation Accelerates Alzheimer-like Neurodegeneration in db/+ Mice via CDK5 HyperactivationSemantic proximity Read

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosisSemantic proximity Read

Up-regulation of cholesterol synthesis pathways and limited neurodegeneration in a knock-in <i>Sod1</i> mutant mouse model of ALSSemantic proximity Read

Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read