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Article

Cutting edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2012

Liu Yaoyang, Yu Yiyun, Matarese Giuseppe, La Cava Antonio

Abstract excerpt

Fasting is beneficial in the prevention and amelioration of the clinical manifestations of autoimmune diseases including systemic lupus erythematosus. The mechanisms responsible for these effects are not well understood. During fasting, there is a dramatic reduction of the levels of circulating leptin, an adipokine with proinflammatory effects. Leptin also inhibits CD4(+)CD25(+)Foxp3(+) regulatory T cells, which...

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Source

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Identifiers

PMID: 22291185
DOI: 10.4049/jimmunol.1102835
PMCID: PMC3288569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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