Article
The pleiotropic roles of leptin in metabolism, immunity, and cancer.
The Journal of experimental medicine - 3 May 2021
de Candia Paola, Prattichizzo Francesco, Garavelli Silvia, Alviggi Carlo, La Cava Antonio, Matarese Giuseppe
Abstract excerpt
The discovery of the archetypal adipocytokine leptin and how it regulates energy homeostasis have represented breakthroughs in our understanding of the endocrine function of the adipose tissue and the biological determinants of human obesity. Investigations on leptin have also been instrumental in identifying physio-pathological connections between metabolic regulation and multiple immunological functions. For...
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