Article
Contributions of the individual domains in human La protein to its RNA 3'-end binding activity.
The Journal of biological chemistry - 20 Jul 2001
Ohndorf U M, Steegborn C, Knijff R, Sondermann P
Abstract excerpt
The autoantigen La regulates the maturation of RNA polymerase III transcripts by binding to their poly(U) termination signal. The modular protein harbors a N-terminal RNA recognition motif (RRM), RRM1, and in the C-terminal domain, a second, atypical RRM2, in addition to a phosphorylation site, and a putative nucleotide binding site. This study presents a detailed investigation into the RNA 3'-end binding...
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