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Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein

18 Oct 2011

Abstract excerpt

Human La protein is an essential factor in the biology of both coding and non-coding RNAs. In the nucleus, La binds primarily to 3' oligoU containing RNAs, while in the cytoplasm La interacts with an array of different mRNAs lacking a 3' UUU(OH) trailer. An example of the latter is the binding of La to the IRES domain IV of the hepatitis C virus (HCV) RNA, which is associated with viral translation stimulation....

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PMID: 22009680
DOI: 10.1093/nar/gkr890

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Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La proteinPMID 22009680Read ↗

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