Article
Generation of hepatitis C virus-specific cytotoxic T lymphocytes from healthy individuals with peptide-pulsed dendritic cells.
Journal of gastroenterology and hepatology - 1 Mar 2001
Ito A, Kanto T, Kuzushita N, Tatsumi T, Sugimoto Y, Miyagi T, Takehara T, Katayama K, Mochizuki K, Hiramatsu N, Kasahara A, Yoshiya I, Sasaki Y, Hori M, Hayashi N
Abstract excerpt
BACKGROUND AND AIMS: In hepatitis C virus (HCV) infection, cytotoxic T lymphocytes (CTL) are involved in liver inflammation and contribute to the reduction of viral load. Antibodies for HCV-CTL precursor frequencies (CTLpf) are relatively low in chronic hepatitis C, and this may be related to the poor CTL response in vivo. The aim of this study was to assess the efficacy of dendritic cells (DC) as...
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