Article
Cytotoxic capacity of hepatitis C virus (HCV)--specific lymphocytes after in vitro immunization with HCV-derived lipopeptides.
Cytometry. Part A : the journal of the International Society for Analytical Cytology - 1 May 2005
Langhans Bettina, Schweitzer Susann, Braunschweiger Ingrid, Schulz Monika, Sauerbruch Tilman, Spengler Ulrich
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV)-derived lipopeptides can induce epitope-specific immune responses in lymphocytes from HCV-naive individuals. We analyzed whether such T cells generated by in vitro immunization with HCV core-derived lipopeptides exert HCV-specific cytolytic activity. METHODS: Using a sensitive flow cytometric cytotoxicity assay we characterized HCV-specific cytotoxicity in T cells generated in...
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